Wrexham will be relieved to return to the comforts of their own home after two difficult away trips to Leyton Orient and Stevenage resulted in just one point and no goals.
The Red Dragons are still second in League One but trail leaders Birmingham by five points and need to continue their 100 per cent record home record to remain in touch.
Northampton are flirting dangerously above the relegation zone following just two league wins all season.
The Cobblers did win on their last trip to Wrexham 1-0 back in February 2006.