Wycombe's winning run came to an end at Exeter on Tuesday but they at least showed impressive character to rescue a point from 2-0 down.
The Chairboys have won their last seven home games, conceding just twice in the process.
Reading are in danger of losing manager Ruben Selles to Hull but they still did the business on the pitch against Cambridge.
The Royals are currently in the final playoff spot and will fancy their chances of pulling off a surprise result.